Tramadol is an analgesic that is central. It has a dual mode of action. The drug is an nonselective antagonist of opioid delta-, muand kappa-receptors. Other mechanisms responsible for delivering the analgesic effects of Tramadol hydrochloride is the inhibition of norepinephrine reuptake by neurons as well as enhancement of the serotonergic responses.
Chronic pain syndrome and acute pain with severe and moderate intensity (pre-and postoperative periods injury, malignancies or neuralgia) and conducting painful therapeutic and diagnostic manipulations.
The dosage and duration of treatment is determined by the physician individually according to the severity of the pain.
Adults and children between 14 and 14 years or older can take (with only a tiny amount of liquid, regardless of their food intake) one capsule (50 mg). If you are suffering from extreme pain, one dose could be two capsules (100 mg).
The recommended daily dosage shouldn't be more than 8 capsules (400 mg).
The medication cannot be used beyond the time period that is justified as a therapeutic the point of. For those with moderate impairments in kidney or liver function, and those who are elderly, the dosage is chosen in a specific manner.
If you have moderate liver impairment It is suggested to decrease the dose or extend the time between doses.
hypersensitivity towards the active ingredient or other constituents that make up the substance. Intoxication with alcohol, acute toxicities with sleep pills psychotropic or analgesic drugs, severe liver dysfunction and renal failure severe epilepsy with frequent attacks. The treatment is not for opioid dependence. Pregnancy or lactation. Children who are younger than 14 years.
An increase in sweating, headache dizziness, weakness anxiety, and confusion can occur. Additionally, there may be nausea and dry mouth, vomiting, constipation, changes in appetite flatulence. In heart, there is tachycardia the sensation of palpitation or an increase in blood pressure may be experienced.
Sometimes Tramadol may trigger dependence for those who are prone to addiction and with long-term usage of large levels of this drug. The abrupt withdrawal that occurs after long-term use of the drug could result in withdrawal syndrome (manifestations like withdrawal signs from prescription drugs like psychomotor agitation, anxiety insomnia, tremors, irritability paraesthesia, phobia attacks hallucinations, disorientation, paranoia, depersonalization, tinnitus and digestive disorders. system).
In the course of therapy, Tramadol should not be used in conjunction with alcohol. When used for a long time addiction and dependence on drugs could be developed. It is not recommended to treat withdrawal symptoms of narcotics.
Be cautious when prescribing the medication in those with injury to the head, high intracranial pressure and moderate impairment to liver or kidney function and patients with an increased risk of having seizures, and patients with higher susceptibility to the opiates. The risk of experiencing seizures can be greater in patients who are taking Tramadol to treat convulsive disorders.
Patients with epilepsy histories and a propensity to epileptic seizures may be prescribed the medication only when it is necessary. The use of caution is to treat patients with impaired respiratory function , or when there is simultaneous treatment with drugs that block the function that the central nervous system due to the possibility of the development of a further respiratory depression.